This coagonist resulted in a significant decrease in body weight and fat mass, demonstrating that balanced simultaneous activation of the both receptors lowered body adiposity and improved glucose tolerance
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Researchers have a few theories for why this might be, ranging from GLP-1s reducing inflammation in the brain and body to helping the brain use glucose more efficiently
The risk increases when GLP-1 drugs are combined with insulin or sulfonylureas, which is why dose adjustments are necessary in combination therapy
