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Yet, whether Rho/ROCK directly mediates TGR5 effects in vivo remains to be confirmed by additional experiments, such as in vivo gene knockout models and Western blot analysis of hypothalamic tissue [68]

This integrated strategy tends to be more conducive to sustained results

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doi: 10.1016/j.cmet.2017.08.004

Consider combining them: Try circuit training that mixes strength moves with short bursts of cardio