However, anaesthetists must be aware that withholding the therapy in patients with type 2 diabetes mellitus may increase the risk of perioperative hyperglycaemia, which can, in turn, elevate the likelihood of postoperative complications, such as wound infections [22]
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This may be explained by a relatively low trial drug exposure (76%) compared to other CVOTs, and that the trial had no run-in period and, therefore, had one of the highest discontinuation rates