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It is used in research settings to investigate cytoprotective signaling and tissue-repair mechanisms, including experimentally reported effects in preclinical models relevant to gastrointestinal mucosal integrity, angiogenic signaling, and inflammatory modulation

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In the 1980s, amidst rising concerns regarding vaccine safety and increasing lawsuits against vaccine manufacturers, the Vaccine Injury Compensation Program (VICP) was birthed through a joint endeavor between vaccine manufacturers and Congress

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