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Alongside GLP-1 RAs, the DPP-4 inhibitors have been developed to exploit the incretin system by prolonging the duration of endogenous GLP-1 (Nauck and Meier, 2016)

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In addition to obesity, IR and diabetes, TMAO is also reported associated with other metabolic dysregulations that related to MAFLD, including dyslipidemia ( The Underlying Mechanisms of TMAO in the Development of MAFLD Although TMAO has been shown to be linked to MAFLD, the molecular mechanisms of TMAO remain obscure