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Oct 2012;46(9):748-51

doi: 10.1007/s00424-018-2195-z

2009 RCT documented improvements in mottled hyperpigmentation alongside fine-wrinkle reduction in photoaged skin 10

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it blocked the binding area of TIGIT to the poliovirus receptor (or CD155), enhanced the function of CD8 + T cells, and inhibited tumor growth 106

From the beginning, patients [should be] counseled that these medications are meant to be bridges, with lifestyle as the foundation, says Class