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How might the weekly dosing regimen of semaglutide impact patient adherence when compared to daily diabetes medication usage

Elife 3 , e02242 (2014)

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During the screening process, 32 patients were excluded because of severe comorbidities,25 patients with history of malignancy were excluded and another 30 were excluded due to incomplete follow-up data

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Food and Drug Administration's (FDA) 2007 report approving the use of pimobendan for dogs, it stated this conclusion in a four week toxicity study of pimobendan administered to 30 previously healthy lab Beagles: "Conclusions: Pimobendan administered IV daily to healthy Beagles caused dose dependent increases in heart rate, mitral valve myxomatous thickening, left ventricular outflow tract endocardial thickening, and ventricular muscle ischemic lesions (multifocal subendocardial necrosis and scarring)