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The phase 2 and phase 3 clinical trials use a systemic stepwise titration to gradually increase the retatrutide dose to help the body adjust and reach the therapeutically effective dose with minimal side effects
A doctor will assess your eligibility
The headline results at 80 weeks were: 12 mg dose: average weight loss of 28.3% (approximately 70.3 lbs / 31.9 kg) 9 mg dose: average weight loss of 25.9% (approximately 64.4 lbs / 29.2 kg) 4 mg dose: average weight loss of 19.0% (approximately 47.2 lbs / 21.4 kg) Placebo: average weight loss of just 2.2% Perhaps most striking was the proportion of patients hitting bariatric-surgery-level outcomes: at the highest dose, 45.3% of participants lost 30% or more of their body weight , and 65.3% reduced their BMI to below 30 kg/m meaning they were no longer classified as living with obesity by the end of the trial
However, a significant increase in Bifidobacterium, Dialister , and Alistipes was reported (73)
Safe use of weight loss injections If your provider determines that youre a good candidate for weight loss medication, they will have you start at the lowest dose, and then gradually increase your dose over time
At the 12mg dose, 28% of participants reported nausea, 24% experienced diarrhea, 21% had constipation, and 17% dealt with some vomiting
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