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patients should remain on 3 mg 1 time a week dose for at least 4 weeks before increasing the dose to 4.5 mg once a week

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GLP-1 Receptor Agonists In patients with HFpEF and comorbid obesity or type 2 diabetes mellitus, semaglutide has been incorporated into the 2025 JCS/JHFS heart failure guidelines with a Class IIa recommendation (Level of Evidence B), reflecting moderate-quality evidence supporting improvement in symptoms and functional status

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