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Analysis based on information available as of December 30, 2025

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Plasma concentrations remained minimal, even at high doses, with most curcumin localized in the small intestine and little reaching systemic circulation, resulting in a bioavailability of approximately 1% (71, 90, 92)

The Permanente Journal, 26 (2), 8997

Genetic variation in GLP-1 receptor density, GIPR signaling, and gut motility genes contributes to differences in nausea severity, appetite suppression magnitude, and fat tolerance

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