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Research indicates that a significant change in weight, typically around 5-10% of your body mass, can cause your periods to become irregular or even cease temporarily, a condition known medically as amenorrhea

An exaggerated postprandial PYY response is observed in gastric bypass patients, and is likely attributed to the increased flow of nutrients into the PYY-rich distal gut, which can directly stimulate L cells (124, 125)

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6 It can also cross the placenta and be found in breast milk

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What the semaglutide evidence covers Semaglutide's weight-management evidence is anchored by the STEP program ( NEJM , 2021)