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[4] Liraglutide has been studied most extensively in this context, with observational studies showing improvements in both weight and metabolic parameters

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PMC 139027

Ultra-pure semaglutide analog for incretin pathway investigation

Acupoint stimulation modulates Glu and its receptors, inhibiting the ascending excitatory pathway by downregulating N -methyl-d-aspartate receptor type 2B and preventing -amino-3-hydroxy-5-methyl-4-isoxazole-propionicacid receptor phosphorylation, thus promoting the recovery of glutamate transporters to clear excessive Glu, thereby contributing to analgesic effects [174, 175]