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GLP-1 drugs have helped millions of Americans lose weight and get healthier, but have also been in short supply as brand-name drugmakers struggle to meet demand

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Unlike a glitazone medication like Actos (pioglitazone), which improves insulin sensitivity, GLP-1 agonists do not mainly work by directly unlocking insulin resistance the way a sensitizer doesalthough weight loss from GLP-1 therapy can indirectly improve insulin sensitivity