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Constitutive MAPK phosphorylation and pharmacodynamic inhibitio of MEK/MAPK in relapsed/refractory primary acute myelogenous leukemia (AML) cells

Moreover, the simulations confirmed that the Cagri P37 had weaker interactions with the ECDs leading to greater uncoupling of the peptide C-terminus from the ECDs (Supplementary Movie 1, Supplementary Tables 4, 5), and parallel increases in the dynamics of the peptide as it engaged with the CTR TM bundle, including F23