Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-10) modified to enhance metabolic stability
The combination of unverified formulation, uncertain sterility, and unknown systemic effects creates a perioperative exposure that cannot be reliably risk-stratified
Inflammasome activation and regulation: Toward a better understanding of complex mechanisms
These observations, reflecting regulatory effects on the transcriptional control of transporters affecting brain UA, demonstrate tissue-specific effects on UA activity, which further question the validity of MR studies discussed above
We propose that while targeting EPAC signaling is an attractive strategy for prevention and interception of localized cutaneous melanoma, targeting the mechanisms that metastatic melanoma cells employ to bypass EPAC signaling is a novel treatment option for advanced melanoma
Artasensi, A., Pedretti, A., Vistoli, G