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The fatigue was on another level

References: Based on STEP 1 (Wilding et al., NEJM 2021) and SURMOUNT-1 (Jastreboff et al., NEJM 2022) trials

Food just stopped being something I thought about constantly

DOI: 10.1093/cid/ciu126

But they also slightly delay gastric emptying

Thus, after ligand binding, the insulin-IR complex is internalized, followed by degradation of the ligand and either degradation, recycling, or translocation of the receptor to other intracellular sites (2325)