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In many cases, copper deficiency may be the missing piece

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However, as with any supplement or treatment, there's potential for side effects, especially when B12 is given in very high doses

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[1] Elongation of telomeres by epitalon was sufficient to surpass the Hayflick limit in a cell culture of human fetal fibroblast cells, extending their proliferative potential from termination at the 34th passage in the control cell population to beyond the 44th passage in the treated cell population, while increasing the lengths of their telomeres to levels comparable to those of cells in the original culture