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According to the recently reported results of a phase 2 trial in patients with gastrointestinal stromal tumors, linsitinib achieved no objective responses in these patients, although the rate of 9-month clinical benefit, progression-free survival, and overall survival at 9 months was 40%, 52% and 80%, respectively [162]

From insulin resistance, chronic inflammation, cardiovascular disease, and MASLD to cancer, BCAA metabolic dysregulation participates in the pathogenesis and progression of various metabolic diseases

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