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The authors suggested that given previous research that formononetin displays slower glucuronidation in intestinal and hepatic microsomes and higher gut permeability [127], formononetin bioavailability have benefited from its structural methylation status making it more liposoluble and improving permeability [126]
Nutrition Journal, 22 , 68
In the European Union, the equivalent is a Clinical Trial Application (CTA)
doi: 10.1038/npp.2010.116 127 GoodarziMOKorenmanSG
5 ResearchGate (2021)Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice
This is particularly relevant in complex tissue injuries where multiple repair processes need coordination
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