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Further investigation has revealed that FANCD1 is the same gene as BRCA2 , a gene that causes predisposition to breast and ovarian cancer.[181] Other Fanconi anemia genes, FANCJ ( BRIP1 ) and FANCN ( PALB2 ), have also been identified as rare breast cancer susceptibility genes.[182] For more information, see the Cancer Risks, Spectrum, and Characteristics section in BRCA1 and BRCA2 : Cancer Risks and Management, or see the BRIP1 , PALB2 , and RAD51 sections in Genetics of Breast and Gynecologic Cancers

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The + 4-oxidation state of Mn in MnO imparts strong oxidative properties, enabling its responsiveness to reducing agents like GSH, allowing it to be rapidly reduced and degraded by GSH

Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss (Hoepken et al., 2007)