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Curr Drug Targ 21(13):13851393 Assis VL, Veras AC, Maciel PM, Albuquerque JG, Zancanella C, Ritto JL, Arajo IGA, Veras RC, Medeiros IA (2020) Effects of Funchicrea, a traditional brazilian herbal complex, on intestinal motility in healthy and constipated rodents
Prioritizing adaptive probe performance over static specificity metrics Small-molecule probes, ligands, and inhibitors inevitably experience off-target interactionsparticularly in redox-active systems where enzymes such as TrxR, GR, and other oxidoreductases share overlapping catalytic motifs, cofactors, and substrate preferences
In contrast, liver sections from the T1 group exhibited severe histopathological alterations
