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Acknowledgements D.P.-R

doi:10.1111/mmi.15032 75

Medical Pharmacology Chapter 2 General Principles: Pharmacokinetics Transition from first-order to zero-order kinetics is described by the Michaelis-Menten model of enzyme kinetics, which provides a mathematical description for saturable, capacity-limited elimination processes

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doi: 10.3389/fendo.2025.1630164 Received 17 May 2025 Accepted 09 July 2025 Published 28 July 2025 Volume 16 - 2025 Edited by Nazli Akin, Vrije University Brussels, Brussels, Belgium Reviewed by Yuan Gao, Gansu Agricultural University, Lanzhou, China Hong-Thuy Bui, International University, Vietnam Updates Copyright 2025 Zhong, Lu, Zhou, Ma, Li, Hu, Wan and Lu

This challenge is exemplified by the early clinical setbacks of ES, which failed to improve overall survival, underscoring the critical need for precise patient stratification based on biomarkers such as mitochondrial metabolic capacity