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These metabolic pathways, rather than a direct anti-proliferative action, may be the target as Metformin decreases hepatic gluconeogenesis, improves insulin sensitivity, reduces insulin and blood glucose levels, and these effects, which also will reduce tumor growth, rather than a direct anti-proliferative action may be the primary target of metformin (55, 248)

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Some patients have mixed feelings about their weight loss because facial fat loss can make them look older

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Why prices stayed high: PBMs inflate list prices to increase their rebate Employers and insurers pay based on the inflated list price Patients pay the list price if uninsured Pharmas net price is much lower than the retail price The U.S

Consider: Will weight loss patients have to take these drugs forever