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We did observe an increase in trophoblast apoptosis in the MUN placenta, which detrimentally lowered the total trophoblast pool

A final alternative to alleviate FcRn-controlled pathological mechanisms could be to alter FcRn in itself, as may be intended with a gene therapy being developed in a collaboration between Beam and Apellis for a one-time dose of gene-editing molecules targeting FcRn [436, 437]

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[6] Magnetic resonance imaging (MRI) scans of the brains of FMS patients have shown significant shrinkage in the hippocampus

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