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In conclusion, we propose a model (Figure 5) in which basic lipophilic compounds accumulate in lysosomes and not only induce cell death due to lysosome membrane permeablization at higher concentrations, but also perturb autophagy process as a result of lysosomal dysfunction at relatively lower concentrations

Depression and anxiety frequently accompany obesity, yet both conditions can improve with weight loss and metabolic stabilization

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Federal law does not require state-licensed pharmacies that are not outsourcing facilities to submit adverse events to the FDA

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Pancreatic stellate cells (PSCs) can have an important role in pancreatitis, secreting various inflammatory cytokines/chemokines, as well as collagen