For most diagnostic purposes, IGF-1 is more reliable
A 2023 observational study of 47 patients using both agent classes reported modest synergistic weight loss (additional 35 lbs over 12 weeks compared to single-agent) but also a 34% incidence of nausea, dizziness, or appetite suppression beyond baseline tirzepatide side effects
Clinical Information Evidence-based details for healthcare providers Use exactly as directed by your healthcare provider
If digestive issues persist or become severe, contact your healthcare provider
31 discontinuation of coverage, and would need to do so again if the coverage is restored
However, this effect has not been conclusively demonstrated in primates, and human thyroid C-cells express GLP-1 receptors at much lower levels than rodent C-cells