pharmacology of semaglutide You might've heard this medication all over the news or on TikTok... but what exactly is it? Today's #MedsYouShouldKnow is all about semaglutide. Semaglutide, also known as Ozempic, Wegovy, and Rybelsus Integrated nutritional-pharmacological strategy for obesity

Westerterp M, Gourion-Arsiquaud S, Murphy AJ, Shih A, Cremers S, Levine RL, Tall AR, Yvan-Charvet L

Estos efectos suelen ser temporales y pueden disminuir con el tiempo

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Discuss risks/benefits with the provider Medications That May Interact: Diabetes medications (insulin, sulfonylureas): Can increase the risk of hypoglycemia (low blood sugar) Dose adjustments needed Oral hormonal contraceptives (birth control pills): Tirzepatide may decrease effectiveness, especially after the first dose and dose increases Switch to a non-oral contraceptive or add a barrier method for 4 weeks after starting and after each dose increase Other GLP-1 medications: Cannot use tirzepatide with Ozempic, Wegovy, Saxenda, Victoza, Mounjaro, Zepbound, Byetta, or Bydureon Cannot combine with other weight loss medications or supplements without provider approval Mental Health Screening During the telehealth consultation, providers screen for: History of depression Suicidal thoughts or behavior Eating disorders (binge eating disorder, bulimia, and anorexia history) GLP-1 medications carry a warning about suicidal behavior and ideation

JAMA psychiatry , 74 (7), 719728

The lack of disease-modifying options underscores the urgent need for novel regenerative therapies backed by rigorous scientific evidence