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Sakai K, DErcole AJ, Murphy LJ, Clemmons DR

There is also ongoing debate about the most suitable product categorywhether food, supplement, or drugand about how to standardize measures of potency, viability, and functional outputs for strains whose benefits may vary significantly depending on context, including baseline microbiome, diet, and host genetics

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In 1970, James Bartley and Roger Chalkley showed that histones of calf thymus nucleohistone are protease resistant when complexed with DNA, whereas when freed from DNA, they rapidly degraded, indicating the presence of DNA-binding-induced structure (Doolittle, 1973)

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