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Subjects were 5 years (SD 2.0) postdiagnosis and had developed HO (mean BMI 37.3, SD 7.1)

In a previous double-blind placebo-controlled phase II trial, 42 self-sufficient subjects (with a score of 3+ on the ALSFRS-R items for swallowing, cutting food and handling utensils, and walking) with ALS [10] received ALCAR 3 g/day and 40 received placebo in an equivalent dose, and were followed for 12 months or until death [11]

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However, variables such as the amount of vitamin C used in the studies, the variety of drugs given to patients, the differences in the patient population, and the duration of use have resulted in disparities in kidney stone outcomes

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All modifications of the receptor had no effect on ligand binding and receptor activation