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When it is finally released, its availability must be more strictly controlled than semaglutide to avoid similar life-threatening usage. Dr Marie Spreckley, of the MRC epidemiology unit at the University of Cambridge, said: Higher discontinuation due to adverse events, particularly gastrointestinal symptoms, is a key consideration and may have implications for tolerability and adherence in real-world settings. She added that because the trial lasted only one year, longer-term safety, cardiovascular outcomes and sustained effectiveness remained important unanswered questions
Common early side effects include mild nausea, constipation, and reduced appetiteside effects that often subside within 1 to 2 weeks
doi: 10.1016/S0140-6736(04)17445-X 67
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