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However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

This D-retro-inverso peptide specifically disrupts the FOXO4-p53 protein interaction that maintains senescent cell viability, providing researchers with a sophisticated tool for investigating cellular senescence biology and its role in aging processes

3 ) ( Table 1 )