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Pathophysiology of IrAEs Several immunopathogenic mechanisms (i.e., cellular autoimmunity, autoantibodies, complement activation, cytokines/chemokines release, genetics and alterations of the gut microbiome) have been suggested to be involved in the development of ICI-related irAEs ( Figure 2 )
Kevin T
Elife 10 , e62174 (2021)
Annu Rev Immunol 30:149173
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