Department of Health and Human Services, FDA is charged with overseeing the safety of many products
Glucagon-like peptide-1 GLP-1 is a 30 amino acid peptide that is produced by and released from intestinal L cells after meal ingestion and which in turn stimulates insulin secretion [5]
Hypoglycemia risk with the combination is lower than with insulin intensification strategies like adding mealtime insulin
Recent clinical studies suggest that Zepbound (tirzepatide) may have a higher success rate in promoting weight loss compared to Wegovy ( semaglutide GLP-1 )
Some supplements, such as berberine, fiber, omega-3s, probiotics, and curcumin, may offer mild metabolic support, but they do not work like prescription GLP-1 drugs and should not be presented as substitutes (Reference)
This uncertainty is itself a concern, unlike well-documented GLP-1 medication side effects that have been thoroughly studied