retatrutide 1mg results Starting my 6th week of Retatrutide, first 4 weeks I kept it to a week, .5mg on Tuesdays and Saturdays. Start of week 5 I upped to 1.5mg a week, .5mg every M/W/F. This is still so new to me but A Clinician's Guide to Retatrutide

Despite this effect, it increases satiety, works favourably on energy expenditure and has lipolytic actions

ROLA EID DR

Diabetologia 50 , 806813 (2007)

Mechanisms deciphered in these studies indicate that the interaction between serotonin and GLP-1 in the hindbrain increases proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neuron activity, leading to induction of satiety signals and suppression of neuropeptide Y/agouti-related peptide (NPY/AgRP) neuron activity, which in turn suppresses hunger

Compared to endogenous GLP-1 and glucagon, retatrutide demonstrates lower potency at GLP-1 and glucagon receptors but substantially higher potency at the human GIP receptor a pharmacological profile deliberately engineered to balance efficacy with tolerability

Ratziu V, Rinella ME, Neuschwander-Tetri BA, Lawitz E, Denham D, Kayali Z, et al