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NAD(+) metabolism: a therapeutic target for age-related metabolic disease

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The pathogenic nexus between diabetes and diabetic kidney disease (DKD) is fundamentally rooted in persistent hyperglycemia, which concurrently fuels three interconnected deleterious pathways: oxidative stress, low-grade inflammation, and accumulation of advanced glycation end products (AGEs)

4), facilitating selection of either the triad or comproportionation model

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