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What sets retatrutide apart from other obesity drugs is its unique mechanism of action, which targets not one, but three distinct hormones in regulating hunger, metabolism, and glucose control
The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes
doi: 10.1038/s41467-024-49655-6
Those are areas where thoughtful coaches remain incredibly valuable
This pathway is for people who are seriously ill, have tried everything else, and cannot join a clinical trial
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