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Nature 288, 675679
This copper-bound form quickly became the focus of research because it showed significant effects on: wound healing collagen synthesis angiogenesis anti-inflammatory signaling Structure and Biochemistry GHK is a simple tripeptide composed of three amino acids: Glycine Histidine Lysine Although structurally small, its biological significance lies in its ability to bind copper ions and transport them to tissues
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The ratio of areas (AUC PO /AUC IV ) reveals oral bioavailability, since AUC is proportional to the amount of drug that was present within the systemic circulation
The DAC version (Drug Affinity Complex) binds to albumin in the blood, which dramatically extends its half-life
