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Pharmacologic activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting antitumor immunity

The objective response rate was 32% (95% CI, 23%41%), with four complete responses and 34 partial responses as assessed by RECIST 1.1 criteria and an independent central review

RT-qPCR results showed a significant increase of Ccl28 in the MI and HI groups compared to the sham group in immunocytes and fibroblasts, but not in other cell types ( Fig

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If a bulk drug substance has impurities, potency drift, or microbial issues, a non-CGMP compounding pathway may not catch it consistently

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