Heckel B (2024) Idiopathic intracranial hypertension after Abrupt Cessation of Medication: a Case Report of Abrupt Glucagon-Like Peptide-1 (GLP-1) receptor Agonist Cessation and Review of the literature
The powder form storage guide covers this in detail
Accessed 09 July 2025 [cited]
GLP-1 medications slow down gastric emptying
Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration
Prescribing outside the licensed indications and doses constitutes off-label use, which requires prescribers to document their rationale, obtain informed consent, and provide appropriate monitoring