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People with a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, kidney problems related to dehydration, pregnancy, or planned pregnancy need individualized medical review

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(ii) Stratification and Long-term Follow-up of Maternal-Fetal Outcomes: Short-term outcomes (miscarriage, preterm birth, structural malformations, placental complications, fetal growth abnormalities) and mid-to-long-term outcomes (offspring growth trajectories, metabolic phenotypes) must be pre-defined within a standardized follow-up framework to assess potential metabolic programming risks

243 Preclinical studies indicate CGA may help regulate cholesterol levels by contributing to the increased expression of cholesterol 7 alpha-hydroxylase (CYP7A1), the enzyme responsible for catalyzing the first step of converting cholesterol to bile acids