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[10] Low NAD+ levels have recently been associated with a variety of age-related ailments and diseases linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss

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These disruptions create a self-perpetuating cycle where reduced SRE leads to greater endothelial dysfunction, compounding the effects of age-related vascular deterioration [45]

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