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Data from the dosing conditions trial (NCT01572753) [15] confirmed the above model-derived conclusions regarding bioavailability: with repeated dosing, the exposure variability was reduced, and the 90% exposure range reduced from approximately 20-fold after the first dose to around five-fold after the tenth dose (Fig

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PKA, in turn, phosphorylates the Kir6.2 and SUR1 subunits of ATP-sensitive potassium (KATP) channels, reducing their activity

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