In XIGDUO XR-treated patients with a diagnosis or strong suspicion of lactic acidosis, prompt hemodialysis is recommended to correct the acidosis and remove accumulated metformin (metformin HCl is dialyzable, with a clearance of up to 170 mL/min under good hemodynamic conditions)
Clinically, the ATTAIN Phase 3 program showed that orforglipron at its highest dose delivered a mean weight loss of 12.4% over 72 weeks, slightly less than the WEGOVY pills 13.6% at 64 weeks, but with a broader, more diverse patient population of over 3,000 participants
References Global GLP-1 Analogues Market to Reach $268.4 Billion by 2030: Consumer Survey commissioned on behalf of Synergy by Suzy LLC and referenced as part of the Carbery Horizon 10 report: Social listening via
We do not promote or encourage any consumption outside of authorised trials
GIP receptor agonism Retatrutide activates glucose-dependent insulinotropic polypeptide (GIP) hormone receptors to enhance insulin secretion and glucose reuptake in cells and slow down gastric emptying
Uncropped SDS-PAGE gels can be found in Supplementary Information (Supplementary Fig