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optional extension to 16 weeks

Several medications and medical conditions may also cause skin flushing

These symptoms are usually mild and subside after a short period

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 80% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Several etiological factors are most likely involved in the pathogenesis of the impaired barrier function in chronic liver disease, but the four most important ones are direct toxicity of alcohol, portal hypertension, alterations in the intestinal microbiome and altered bile acid signaling

E., Olsen, E