2012;7:e42365
The HCA 2 receptor activates an associated G i -type G-protein which inhibits the production of cAMP, thereby reducing the PKA-mediated phosphorylation and activation of hormone-sensitive lipase, HSL
These findings suggest that research into the therapeutic modulation of FOXO4 activity, such as through the use of the synthetic peptide FOXO4-DRI, could provide insight into the heart's natural protective mechanisms and degenerative changes associated with aging
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doi: 10.1136/bmj.324.7352.1488 211 WangXMWuTXHamzaMRamsayESWahlSMDionneRA
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