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Non-randomized trial of dornase alfa for acute respiratory distress syndrome secondary to Covid-19

The mean absolute bioavailability following intramuscular injection was approximately 14-19% in rats and 45-51% in beagle dogs, suggesting species-specific absorption characteristics relevant for dose translation to human applications

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67 A recent cohort study suggests similar efficacy for MTX and MMF between subtypes of CLE, suggesting that other factors such as side-effect profile and comorbid conditions may influence medication selection