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CADTH identified several areas of uncertainty to the sponsors analysis that have notable implications on the results of the BIA: Market share assumptions were considered uncertain: Due to limited data, the sponsor made assumptions regarding the future market share of oral semaglutide, including assuming | % market share would be taken from |, and |% will come from |||

Celada, P., Puig, M

patients who skip doses see diminished results regardless of delivery method

For GSH_d, the key binding residues are D167, R177, I179, S165, Q357, and K315 (Table 3)

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