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Published studies consistently show GLP-1 receptor agonists slow gastric emptying and influence intestinal movement

These symptoms get better after a few weeks

GLP-1 Receptor Activation and Gastric Motility GLP-1 receptor activation slows gastric emptying

Nelson K,Jackson A,Gingerich T,Fahlman A,Lessenich C,Fennell F,Ventura D,Roy P,Keith D,Sheppard B,Brody JR,Mills GB,Ronai ZA,Sears RC

The two Phase II failures together, in populations chosen because they might plausibly benefit, are why the program did not continue

After filtering on samples passing SomaLogic quality control (RowCheck = =TRUE) and selecting aptamers targeting human proteins, the remaining data covering 7,289 aptamers were log 10 transformed and, for each aptamer, all measurements standardized using the mean and standard deviation (s.d.) of samples obtained at baseline