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Injecting too shallowly (into dermal tissue rather than subcutaneous fat) reduces absorption rate and increases local irritation

Moreover, GO sheets carry negative charges from ionized functional groups like carboxyl and hydroxyl, creating opportunities for electrostatic interactions with positively charged ions or molecules such as metal ions and industrial cationic dyes like methylene blue (MB) 122,159

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According to one comprehensive analysis, knee OA has been sharply on the rise over the past three decades, with over 3 million cases reported world-wide in 2021, compared to only 1.4 million in 1990

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