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DPP-4 inhibitors may be a treatment option for patients in whom metformin is contraindicated due to decreased renal function or intolerable gastrointestinal side effects

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In another study, researchers found that combining glutathione with L-citrulline maximizes the production of nitric oxide, which dilates the blood vessels to improve blood flow and oxygen delivery to muscles and tissue [10]

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However, its also worth noting that poorly managed diabetes can cause nerve damage over time, possibly resulting in muscle aches, numbness, and tingling, Dr

SGLT2 inhibitors can also be considered for their weight loss and cardiovascular benefits